MovDisordV3, Main, Exploration, bibRecord, 000605

Development of a prediction formula of Parkinson disease severity by optical coherence tomography.

Identifieur interne : 000605 ( Main/Exploration ); précédent : 000604; suivant : 000606

Development of a prediction formula of Parkinson disease severity by optical coherence tomography.

Auteurs : Beatriz Jiménez [Espagne] ; Francisco J. Ascaso ; José A. Crist Bal ; Javier L Pez Del Val

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.

RBID : pubmed:24458320

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Nerve Fibers (pathology), Parkinson Disease (diagnosis), Parkinson Disease (pathology), Predictive Value of Tests, Retina (pathology), Tomography, Optical Coherence.
MESH :
- diagnosis : Parkinson Disease.
- pathology : Nerve Fibers, Parkinson Disease, Retina.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Tomography, Optical Coherence.

Abstract

The aims of this study were to assess the peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease (PD), to determine its correlation with disease severity, and to define a simple biomarker for predicting clinical severity. One hundred two eyes from 52 patients affected by PD were compared with 97 eyes from 50 age-comparable controls. In all patients, peripapillary RNFL thickness was measured by optical coherence tomography (OCT). We used the Unified Parkinson's Disease Rating Scale (UPDRS) total score and measured responses in the on medication state. Eyes from patients with PD had a statistically significant decrease in average peripapillary RNFL thickness compared with control eyes (P < 0.001). This reduction was observed in every quadrant (inferior, superior, nasal [P < 0.001], and temporal [P = 0.017]) in patients with PD. Furthermore, a strong inverse correlation was found between the PD severity measured according to the UPDRS score and the average peripapillary RNFL thickness (r = -0.615; P < 0.001) and PD duration (r = -0.303; P = 0.002). From these results, we defined a regression equation that predicts the UPDRS score from the above-mentioned variables: UPDRS = 81.6 + 29.6 * log PD duration (years) - 0.6 * RFNL thickness (μm). We observed that, as the evolution and severity of PD progress, the peripapillary RNFL layer thickness, as evaluated by OCT, gradually diminishes. These results suggest that the average peripapillary RNFL thickness measured by OCT might be useful as a biomarker to detect the early onset and progression of PD.

DOI: 10.1002/mds.25747
PubMed: 24458320

Affiliations:

Espagne

Le document en format XML

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<author><name sortKey="Ascaso, Francisco J" sort="Ascaso, Francisco J" uniqKey="Ascaso F" first="Francisco J" last="Ascaso">Francisco J. Ascaso</name>
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<author><name sortKey="Crist Bal, Jose A" sort="Crist Bal, Jose A" uniqKey="Crist Bal J" first="José A" last="Crist Bal">José A. Crist Bal</name>
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<author><name sortKey="L Pez Del Val, Javier" sort="L Pez Del Val, Javier" uniqKey="L Pez Del Val J" first="Javier" last="L Pez Del Val">Javier L Pez Del Val</name>
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<term>Nerve Fibers (pathology)</term>
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<term>Parkinson Disease (pathology)</term>
<term>Predictive Value of Tests</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nerve Fibers</term>
<term>Parkinson Disease</term>
<term>Retina</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The aims of this study were to assess the peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease (PD), to determine its correlation with disease severity, and to define a simple biomarker for predicting clinical severity. One hundred two eyes from 52 patients affected by PD were compared with 97 eyes from 50 age-comparable controls. In all patients, peripapillary RNFL thickness was measured by optical coherence tomography (OCT). We used the Unified Parkinson's Disease Rating Scale (UPDRS) total score and measured responses in the on medication state. Eyes from patients with PD had a statistically significant decrease in average peripapillary RNFL thickness compared with control eyes (P < 0.001). This reduction was observed in every quadrant (inferior, superior, nasal [P < 0.001], and temporal [P = 0.017]) in patients with PD. Furthermore, a strong inverse correlation was found between the PD severity measured according to the UPDRS score and the average peripapillary RNFL thickness (r = -0.615; P < 0.001) and PD duration (r = -0.303; P = 0.002). From these results, we defined a regression equation that predicts the UPDRS score from the above-mentioned variables: UPDRS = 81.6 + 29.6 * log PD duration (years) - 0.6 * RFNL thickness (μm). We observed that, as the evolution and severity of PD progress, the peripapillary RNFL layer thickness, as evaluated by OCT, gradually diminishes. These results suggest that the average peripapillary RNFL thickness measured by OCT might be useful as a biomarker to detect the early onset and progression of PD.</div>
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<name sortKey="Crist Bal, Jose A" sort="Crist Bal, Jose A" uniqKey="Crist Bal J" first="José A" last="Crist Bal">José A. Crist Bal</name>
<name sortKey="L Pez Del Val, Javier" sort="L Pez Del Val, Javier" uniqKey="L Pez Del Val J" first="Javier" last="L Pez Del Val">Javier L Pez Del Val</name>
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<country name="Espagne"><noRegion><name sortKey="Jimenez, Beatriz" sort="Jimenez, Beatriz" uniqKey="Jimenez B" first="Beatriz" last="Jiménez">Beatriz Jiménez</name>
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Movement Disorders (revue)

Development of a prediction formula of Parkinson disease severity by optical coherence tomography.

Development of a prediction formula of Parkinson disease severity by optical coherence tomography.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.